Antihypertensive drugs

Antihypertensive drugs

Antihypertensive drugs

Application Number
400320
Method
TLC
Results

Substances
metoprolol; H 119/66 (metoprolol metabolite); acebutolol; M&B 16942 (acebutolol metabolite); oxprenolol; propranolol; nadolol; methyltriazolophthalazine; atenolol; labetalol; pindolol; alprenolol; sotalol; dihydralazine
Product(s)
PhaseREFWebshop

SIL N-HR

804023

Matrix
urine
Sample(s)
Conditions

1st development: Eluent 1: ethyl acetate - methanol (40:5, v/v), 5 cm ascending , then view under UV

2nd development: Eluent 2: ethyl acetate - methanol - aqueous ammonia solution, d=0.88, (40:5:5, v/v), 8 cm ascending

Detection
A) UV, 254 nm B) conc. sulfuric acid, then UV C) 38 % aqueous formaldehyde solution in conc. sulfuric acid (1:10, v/v), then UV D) ammonium metavanadate in conc. sulfuric acid
Note
Author
Jack, D.
Source
J. Chromatogr. 187 (1980) 277
Disclaimer
Concerning questions to literature applications please contact the cited author/s. Chemicals mentioned in applications are not manufactured or sold by MACHEREY-NAGEL. Applications mentioned in MACHEREY-NAGEL literature or databases are provided for informational purposes only. MACHEREY-NAGEL does not warrant that all applications have been tested in MACHEREY-NAGEL laboratories using MACHEREY-NAGEL products. MACHEREY-NAGEL does not warrant the correctness of the applications.
Dateien
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