Preparation of lipid-based formulations Lipid-based formulations containing curcumin (drug loading = 30 mg/g of excipient) and lipid-based formulations containing β-arteether (drug loading = 200 mg/g of excipient) were prepared. (For details see the cited literature.)

Standard sample preparation The preparation of all the standard samples was performed protected from light. Unless otherwise specified, the working standard solutions, the calibration standards, the quality control samples and the validation standards were obtained after appropriate dilution in the mixture of methanol and 10 mmol/L ammonium acetate (pH 4) (50:50, v/v). (More information in the cited literature.)

Eluent: methanol - 10 mmol/L ammonium acetate, pH 4 (80:20, v/v) Flow rate: 0.45 mL/min Temperature: 32.5 °C Injection volume: 50 µL