Hydromorphone and dipyrone in PCA-devices: Is this still a therapy with hydromorphone?

Hydromorphone and dipyrone in PCA-devices: Is this still a therapy with hydromorphone?

Hydromorphone and dipyrone in PCA-devices: Is this still a therapy with hydromorphone?

Application Number
126210
Method
HPLC
Results

Legend:
? - possible prodrug

Substances
hydromorphone; dipyrone, 4-MAA (dipyrone metabolite)
Product(s)
PhaseREFWebshop

NUCLEODUR 100-5 C18 ec

760001.40

Matrix
Sample(s)

PCA-devices (devices of patient-controlled analgesia), used in the oncological and palliative pain therapy, were stored under light protection at different temperature (37 °C, room temp., refrigerator temp.). To evaluate the chemical compatibility of hydromorphone with dipyrone the content is determined by HPLC.

Conditions

Eluent A: sodium phosphate buffer, pH 5 Eluent B: acetonitrile Gradient: 5-30 % B in 15 min Flow rate: 1 mL/min

Detection
UV-DAD
Note
Author
Müller, S. et al.
Source
University Hospital Freiburg, Department of Pharmacy (Germany) Poster P-76, 2nd PharmSciFair, Nice (France), 09. June 2009
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