Separation of the four optical isomers of a dihydropyridine calcium channel antagonist

Separation of the four optical isomers of a dihydropyridine calcium channel antagonist

Separation of the four optical isomers of a dihydropyridine calcium channel antagonist

Application Number
105620
Method
HPLC
Results

Legend:
HPLC separation of the RS-93522-004 bis-camphanate diastereomers, sample concentration approx. 0.3 mg/mL, sample loading approx. 6 µg

Substances
RS-93522-004; 2-[4-(2; 3-dihydroxypropoxy)phenyl]ethyl 1; 4-dihydro-2; 6-dimethyl-4-(3-nitrophenyl)-3; 5-pyridinedicarboxylate
Product(s)
PhaseREFWebshop

NUCLEOSIL SiOH

720099.46

Matrix
Sample(s)

Derivatization with ( - )-camphanic acid chloride

Conditions

Eluent: 0.1 % acetonitrile and 4 % 2-propanol in isooctane (2,2,4-trimethylpentane) Flow rate: 2.0 mL/min Temperature: 50 °C

Detection
UV, 229 nm
Note
Author
Ward, K.D. et al.
Source
J. Chromatogr. 478 (1989) 169 - 179
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